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In the realm of men’s health, many people believe that medications such as Cialis (tadalafil) and generic sildenafil (Viagra) can help in treating erectile dysfunction (ED). However, these medications do not address ED, and many individuals may prefer to use a brand-name version of either drug to treat their ED. Fortunately, there are several effective and affordable solutions to help you achieve a healthy and satisfying sexual experience.

In this article, we will delve deeper into the science behind Cialis (tadalafil), the primary medication used to treat erectile dysfunction. Understanding the benefits of using Cialis and its mechanisms of action is essential for making informed decisions about its use. In this article, we will explore the benefits of using Cialis and its mechanism of action to help men achieve and maintain erections.

Benefits of Using Cialis and Its Mechanism of Action

One of the primary benefits of using Cialis is its ability to treat erectile dysfunction (ED). ED is a common problem that affects millions of men worldwide. In fact, over 30 million ED cases are reported each year. However, many men experience an inability to achieve or maintain an erection adequate enough for sexual activity. ED is a common issue that affects millions of men in the United States, affecting nearly 5.2 million men in the U. S. alone.

ED can be caused by a variety of factors. Some common causes include:

  • Low testosterone levels
  • Poor blood flow to the penis
  • High blood pressure
  • Diabetes
  • Obesity
  • Obesity and cardiovascular disease
  • Poor blood circulation to the penis
  • Stress
  • Hormonal imbalances
  • Certain medications and medical conditions

Other factors that may contribute to ED include:

    ED can be a serious problem that requires immediate attention. Fortunately, there are several treatment options available to help individuals maintain an erection. Several medications are available to help men with ED. These medications can be categorized into phosphodiesterase type 5 inhibitors (PDE5 inhibitors), which are used for the treatment of ED. PDE5 inhibitors are a type of PDE5 inhibitor that works by relaxing blood vessels and increasing blood flow to the penis.

    Phosphodiesterase Type 5 Inhibitors (PDE5 inhibitors)

    There are several types of PDE5 inhibitors available, including sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra). These medications are used for the treatment of ED and the underlying causes of ED. Sildenafil, on the other hand, is a PDE5 inhibitor that works by increasing blood flow to the penis. The mechanism of action of sildenafil is to increase nitric oxide levels in the penile tissue, which helps to relax blood vessels and increase blood flow.

    Tadalafil, on the other hand, is a PDE5 inhibitor that is primarily used to treat erectile dysfunction. Tadalafil has a longer half-life than sildenafil, leading to a higher rate of absorption and onset of action than sildenafil. This makes it an effective medication for ED. However, it is important to note that Tadalafil has a shorter half-life, which means it takes longer for it to start working.

    Vardenafil, on the other hand, is a PDE5 inhibitor that is used to treat erectile dysfunction and is effective in treating the underlying cause of ED. Vardenafil has a longer half-life, which means it is taken more frequently, which may help men with ED more easily achieve and maintain erections. However, it is important to note that Vardenafil is not a controlled substance, and it is not an approved medication for treating ED.

    Generic Sildenafil (Viagra)

    Generic sildenafil (Viagra) is a brand-name version of tadalafil. It is a prescription medication used to treat ED and is available in various forms, including oral tablets, oral capsules, and topical solutions. It works by increasing blood flow to the penis, helping to achieve and maintain an erection when sexually aroused.

    Interactions

    A. Top Drug-Drug Interactions:

    1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

    2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

    3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

    Other Drug-Drug interactions:

    • Ketoconazole, itraconazole (used to manage fungal infection)
    • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
    • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
    • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
    • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

    B. Drug-Food Interactions:

    Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

    1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
    2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
    3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
    4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
    EUCAST infections

    Combining Cialis and Other Drugs:

    Taking lower dosages of these medications together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or orthostatic hypotension.

    6.: Both Cialis and nitroglycerin can interact with nitrates known to lower blood pressure, leading to a significant and potentially dangerous drop in blood pressure (hypertension).

    7.: Nitrates known to lower blood pressure on the high street can accumulate in the blood vessels of your eyes, causing them to become narrow, which can make it difficult to open and keep an eye on blood pressure. This can cause them to become unsafe to use. Always consult your doctor before taking medications to prevent overmedying your eyes.

    8.

    Erectile Dysfunction

    Erection problems (impotence) are very common, particularly in men over 40.

    Most men occasionally fail to get or keep an erection. This is usually due to stress, tiredness, anxiety or drinking too much alcohol, and it’s nothing to worry about.

    If it happens more often, it may be caused by physical or emotional problems.

    Physical causes Possible cause Treatment Narrowing of penis blood vessels, high blood pressure, high cholesterol medicine to lower blood pressure, statins to lower cholesterol Hormone problems hormone replacement – for example, testosterone Side effects of prescribed medication change to medicine following discussion with GP You may also be asked to make lifestyle changes.

    Do lose weight if you’re overweight stop smoking eat a healthy diet exercise daily try to reduce stress and anxiety

    Don’t cycle for a while (if you cycle more than 3 hours a week) drink more than 14 units of alcohol a week

  • Side Effects

    Possible side effects

    Like all medicines, this medicine can cause side effects, although not everybody gets them. These effects are normally mild to moderate in nature.

    If you experience any of the following side effects stop using the medicine and seek medical help immediately:

    allergic reactions including rashes (frequency uncommon). chest pain – do not use nitrates but seek immediate medical assistance (frequency uncommon). priapism, a prolonged and possibly painful erection after taking CIALIS (frequency rare). If you have such an erection, which lasts continuously for more than 4 hours you should contact a doctor immediately. sudden loss of vision (frequency rare). Other side effects have been reported:

    Common (seen in 1 to 10 in every 100 patients)

    headache, back pain, muscle aches, pain in arms and legs, facial flushing, nasal congestion, and indigestion. Uncommon (seen in 1 to 10 in every 1,000 patients)

    dizziness, stomach ache, feeling sick, being sick (vomiting), reflux, blurred vision, eye pain, difficulty in breathing, presence of blood in urine, prolonged erection, pounding heartbeat sensation, a fast heart rate, high blood pressure, low blood pressure, nose bleeds, ringing in the ears, swelling of the hands, feet or ankles and feeling tired. Rare (seen in 1 to 10 in every 10,000 patients)

    fainting, seizures and passing memory loss, swelling of the eyelids, red eyes, sudden decrease or loss of hearing, hives (itchy red welts on the surface of the skin), penile bleeding, presence of blood in semen and increased sweating. Heart attack and stroke have also been reported rarely in men taking CIALIS. Most of these men had known heart problems before taking this medicine.

    Partial, temporary, or permanent decrease or loss of vision in one or both eyes has been rarely reported.

  • [+dl-citirutamide]

    Form

    Inhibium

    Active ingredient -Citrobacter freundii

  • Ingredients

    Active Ingredients - citric acid, hydrochloric acid, potassium hydroxide, magnesium hydroxide, sodium hydroxide, potassium phosphate, sodium starch glycolate, cellulose acetate, hydroxypropyl cellulose, hydroxypropyl cellulose, hypromellose, macrogol (a macrogol family), titanium dioxide, benzyl alcohol, and sodium benzoate.

    Contains caffeine -caffeine

    Colour - white -sodium hydroxide

    Other ingredients - lactose, magnesium stearate, talc - black iron oxide, polyethylene glycol, povidone, sodium starch glycolate, cellulose acetate, FD& C Blue No. 2, edible ink - cetyl palmitate, cetyl alcohol, stearyl alcohol, white - iron oxide, talc - tern, titanium dioxide - yellow iron oxide, benzyl alcohol, and mineral oil.

  • Whether you can take Tadalafil at the same time as your other medications will depend on which medications you are taking.

    You are required to complete a short medical consultation questionnaire that asks for any medications that you are prescribed from your GP and will indicate the medications that can’t be taken alongside Tadalafil.

    There are several medicines which should not be taken concurrently with Tadalafil. Medicines which can have potentially serious interactions with Tadalafil include :-

    • Any alpha-blocker medicines e.g. doxazosin (Cardura), alfuzosin (Xatral), tamsulosin, terazosin, or Flomax, that you can buy in the pharmacy. (These medicines may be used to treat prostate problems or high blood pressure).

    • Isosorbide mononitrate, isosorbide dinitrate, or use a GTN spray or tablets

    for chest pain or use Rectogesic ointment?

    • Nicorandil (Ikorel), used to treat angina

    • Cimetidine, used to treat stomach or duodenal (peptic) ulcers

    • Theophylline, used to treat asthma

    • Antibiotics:- Clarithromycin, Erythromycin and Telithromycin

    • Anti-fungals such as itraconazole and ketoconazole

    • Seizure medication:- carbamazepine, oxcarbazepine, phenobarbital, phenytoin and primidone

    • Heart or blood pressure medication:- disopyramide, amiodarone, quinidine and procainamide

    • Anti-viral medication:- telaprevir, atazanavir, retonavir, indinavir, saquinavir and cobicistat

    • Recreational drugs:- amyl nitrate (poppers)

    If you are taking any prescribed medication from your GP then you can simply write those in the “Is there any other medical information that you think our doctor should know?” section on the medical questionnaire. Then, our doctor will know whether the Tadalafil is safe for you to take.

    Read available consultation questionnaire information

    Tadalafil vs Cialis: Which is better

    Tadalafil and Cialis are both type II inhibitors ofTadalafil. However, they are slightly more similar than each other and more similar to angina or high blood pressure than salt and fluid retention.

    Tadalafil has been approved for clinical trials for treatment of high blood pressure in combination with low blood pressure treatment in individuals over 40.

    Tadalafil vs Cialis: Which is better information GP consultation questionnaire information

    What is Tadalafil?

    Tadalafil is the generic version of Cialis. It is available as a online pharmacy service and as a generic medicine from Dr Fox.

    Tadalafil is the active ingredient of both Cialis and as the active ingredient of Cialis from manufacturers including CVS, Walgreens and GPhC.

    Tadalafil is co-administered as the first line of treatment with Cialis and as the first treatment with Tadalafil from Dr Fox after it was approved by the FDA to treat erectile dysfunction in adult men.